Prof. Dr. med.

Hasan
Kulaksiz

Sprachen

  • Deutsch
  • Englisch
  • Türkisch
  • Serbisch

Mitgliedschaften

  • Schweizerische Gesellschaft für Gastroenterologie (SGGSSG)
  • Aerztegesellschaft des Kantons Zürich (AGZ)
  • Deutsche Gesellschaft für Endoskopie und Bildgebende Verfahren e.V. (DGE-BV)
  • Deutsche Gesellschaft für Verdauungs- und Stoffwechselerkrankungen (DGVS)
  • Deutsche Krebsgesellschaft e. V. (DKG)
1989 – 1996 Medizinstudium in Hannover und San Antonio (USA)
1996 Staatsexamen, Medizinische Hochschule Hannover (MHH)
1996 Dissertation mit summa cum laude, MHH
2005 Facharzt für Innere Medizin, Universitätsklinikum Heidelberg
2005 Oberarzt für Innere Medizin, Schwerpunkt Endoskopie, Universitätsklinikum Heidelberg
2005 Habilitation und Venia legendi für das Fach Innere Medizin, Universitätsklinikum Heidelberg
2006 Facharzt für Gastroenterologie und Hepatologie, Universitätsklinikum Heidelberg
2006 - 2007 Zertifikat „Führung und Verantwortung im Krankenhaus“ Verwaltungs- und Wirtschaftsakademie Baden-Württemberg
2007 - 2011 Leitender Arzt Endoskopie und Hepatologie, Universitätsklinikum Ulm
2008 Ernennung zum apl. Professor der Universität Ulm
2010 Facharzt für Intensivmedizin
2010 Fachkunde im Strahlenschutz
2011 - 2015 Chefarzt für Gastroenterologie und Hepatologie, Spital Waldshut-Tiengen
2011 – 2013 Etablierung der komplexen und interventionellen Endoskopie, Spital Waldshut-Tiengen
2012 Eröffnung des Tumorzentrums Hochrhein
2011 – 2014 Etablierung Akademisches Lehrkrankenhaus
2014 Ernennung zum apl. Professor der Universität Freiburg
2016 Chefarzt für Gastroenterologie und Innere Medizin, Ev. Krankenhaus Hagen-Haspe
Jan. 2017

Gemeinschaftspraxis für Magen-Darmkrankeiten,
Zentrum für Gastroenterologie und Hepatologie Klinik Im Park

Endoskopie

  • Strnad P, von Figura G, Gruss R, Jareis KM, Stiehl A, Kulaksiz H. Oblique bile duct predisposes to the recurrence of bile duct stones. PLoS One 2013; 8; e54601
  • Kulaksiz H, Strnad P, Thomas Barth, Schirmacher P, Adler G, Stiehl A. A novel method of forceps biopsy improves the diagnosis of proximal biliary malignancies. Dig Dis Sci 2011; 56; 596-601
  • Rudolph G, Gotthardt D, Kloeters-Plachky P, Rost D, Kulaksiz H, Stiehl A. In PSC with dominant bile duct stenosis, IBD is associated with an increase of carcinomas and reduced survival. J Hepatol. 2010; 53; 313-317
  • Gotthardt DN, Rudolph G, Klöters-Plachky P, Kulaksiz H, Stiehl A. Endoscopic dilation of dominant stenoses in primary sclerosing cholangitis: outcome after long-term treatment. Gastrointest Endosc 2010; 71: 527-534
  • Rudolph G, Gotthardt D, Klöters-Plachky P, Kulaksiz H, Rost D, Stiehl A. Influence of dominant bile duct stenoses and biliary infections on outcome in primary sclerosing cholangitis. J Hepatol 2009; 51;149-155
  • von Figura G, Stephani J, Wagner M, Wegener M, Wolf C, Adler G, Kulaksiz H. Secondary sclerosing cholangitis after chemotherapy with bevacizumab and paclitaxel. Endoscopy 2009; 41; E153-154
  • Kulaksiz H, Weiss KH, Gotthardt D, Adler G, Stremmel W, Schaible A, Dogan A, Stiehl A, Sauer P. Is stenting necessary after balloon dilatation of post-transplantation biliary strictures? Results of a prospective comparative study. Endoscopy 2008; 40; 746-751
  • Kulaksiz H, Heuberger D, Engler S, Stiehl A. Poor outcome in progressive sclerosing cholangitis after septic shock. Endoscopy 2008; 40; 214-218
  • Rost D, Kulaksiz H, Stiehl A. Treatment of Primary Sclerosing Cholangitis. Current Treatment Options in Gastroenterology 2007; 10.2; 111-119
  • Eisenbach C, Merle U, Schirmacher P, Hansmann J, Stiehl A, Stremmel W, Kulaksiz H. Perforation of the esophagus after dilation treatment for dysphagia in eosinophilic esophagitis. Endoscopy 2006; 38; E43-44

Endokrinologie

  • Schwarz P, Strnad P, von Figura G, Janetzko A, Krayenbühl P, Adler G, Kulaksiz H. A novel monoclonal antibody immunoassay for the detection of human serum hepcidin. J Gastroenterol. 2011; 46; 648-656
  • Schwarz P, Strnad P, Singer N, Oswald F, Ehehalt R, Adler G, Kulaksiz H. Identification, sequencing, and cellular localization of hepcidin in guinea pig (Carvia porcellus). J Endocrinol 2009; 202;389-396
  • Kulaksiz H, Fein E, Redecker P, Stremmel W, Adler G, Cetin Y. Pancreatic ß-cells express hepcidin, an iron-uptake regulatory peptide. J Endocrinol 2008; 197; 241-249
  • Fein E, Merle U, Ehehalt R, Kulaksiz H. Regulation of hepcidin in HepG2 and RINm5F cells. Peptides 2007; 28; 951-957
  • Kulaksiz H, Theilig F, Bachmann S, Gehrke SG, Rost D, Janetzko A, Cetin Y, Stremmel W. The iron-regulatory peptide hormone hepcidin: expression and cellular localization in the mammalian kidney. J Endocrinology 2005; 184; 361-370
  • Kulaksiz H, Schlenker T, Rost D, Stiehl A, Volkmann M, Lehnert T, Cetin Y, Stremmel W. Guanylin regulates chloride secretion in the human gallbladder via the bile fluid. Gastroenterology 2004; 126; 732-740
  • Kulaksiz H, Gehrke S, Janetzko A, Rost D, Bruckner T, Kallinowski B, Stremmel W. Pro-hepcidin: expression and cell-specific localization in the liver and its regulation in hereditary hemochromatosis, chronic renal insufficiency, and renal anemia. Gut 2004; 53; 735-743
  • Kulaksiz H, Schmid A, Hönscheid M, Ramaswamy A, Cetin Y. Clara cell impact in air-side activation of CFTR in small pulmonary airways. Proc Natl Acad Sci USA 2002; 99; 6796-6801
  • Kulaksiz H, Schmid A, Hönscheid M, Eissele R, Klempnauer J, Cetin Y. Guanylin in the human pancreas: a novel luminocrine regulatory pathway of electrolyte secretion via cGMP and CFTR in the ductal system. Histochem Cell Biol 2001; 115: 131-145
  • Kulaksiz H, Cetin Y. Uroguanylin and guanylate cyclase C in the human pancreas: expression and mutuality of ligand-receptor localization as indicators of intercellular paracrine signaling pathways. J Endocrinology 2001; 170; 267-275
  • Kulaksiz H, Arnold R, Göke B, Maronde E, Meyer M, Fahrenholz F, Forssmann WG, Eissele R. Expression and cell-specific localization of the cholecystokinin B/gastrin receptor in the human stomach. Cell Tissue Res 2000; 299: 289-298
  • Kuhn, M., Kulaksiz, H., Adermann, K., Rechkemmer, G., Forssmann, W.G. Radioimmunoassay for circulating human guanylin. FEBS Lett 1994; 314: 218 - 222

Infektiologie

  • Schwarz P, Strnad P, von Figura G, Janetzko A, Krayenbühl P, Adler G, Kulaksiz H. A novel monoclonal antibody immunoassay for the detection of human serum hepcidin. J Gastroenterol. 2011; 46; 648-656
  • Schwarz, P, Strnad P, Adler G, Kulaksiz H. Hepcidin is localized in gastric parietal cells, regulates acid secretion and is induced by H. pylori infection. GUT 2012; 61; 193-201
  • Strnad P, Schwarz P, Rasenack MC, Kucukoglu O, Habib RI, Heuberger D, Ehehalt R, Müller MW, Stiehl A, Adler G, Kulaksiz H. Hepcidin is an antibacterial, stress-inducible peptide of the biliary system. PLoS One. 2011; 6; e16454
  • Merle U, Fein E, Gehrke SG, Stremmel W, Kulaksiz H. The iron regulatory peptide hepcidin is expressed in the heart and regulated by hypoxia and inflammation. Endocrinology 2007; 148; 2663-2668
  • Kulaksiz H, Rudolph G, Kloeters-Plachky P, Sauer P, Geiss H, Stiehl A. Biliary candida infections in primary sclerosing cholangitis. J Hepatol 2006; 45; 711-716

Onkologie

  • Rudolph G, Gotthardt DN, Kloeters-Plachky P, Kulaksiz H, Schirmacher P, Stiehl A. In PSC with colitis treated with UDCA, most colonic carcinomas develop in the first years after the start of treatment. Dig Dis Sci 2011; 56; 3624-3630
  • von Figura G, Hartmann D, Pauls S, Barth TF, Adler G, Henne-Bruns D, Kulaksiz H. Difficult diagnosis of a large cystic retroperitoneal tumor mimicking a hepatic origin. Z Gastroenterol 2010; 48; 1301-1304
  • Ehehalt R, Krautter M, Zorn M, Sparla R, Fullekrug J, Kulaksiz H, Stremmel W. Increased basolateral sorting of carcinoembryonic antigen in a polarized colon carcinoma cell line after cholesterol depletion-Implications for treatment of inflammatory bowel disease. World J Gastroenterol 2008; 14; 1528-1533
  • Bekeredjian R, Kroll RD, Fein E, Tinkov S, Coester C, Winter G, Katus HA, Kulaksiz H. Ultrasound targeted microbubble destruction increases capillary permeability in hepatomas. Ultrasound in Medicine and Biology 2007; 33; 1592-1598
  • Rau S, Autschbach F, Riedel HD, Konig J, Kulaksiz H, Stiehl A, Riemann JF, Rost D. Expression of the multidrug resistance proteins MRP2 and MRP3 in human cholangiocellular carcinomas. Eur J Clin Invest 2008; 38; 134-142
  • Kloeters O, Friess H, Giese N, Buchler MW, Cetin Y, Kulaksiz H. Uroguanylin inhibits proliferation of pancreatic cancer cells. Scan J Gastroenterol 2008; 43; 447-455
  • Kulaksiz H, Rehberg E, Stremmel W, Cetin Y. Guanylin and functional coupling proteins in the human salivary glands and gland tumors. Am J Pathol 2002; 161; 655-664
  • Kulaksiz H, Eissele R, Rössler D, Schulz S, Höllt V, Cetin Y, Arnold R. Identification of somatostatin receptor subtypes 1, 2A, 3 and 5 in neuroendocrine tumors with subtype-specific antibodies. Gut 2002; 50: 52-60

Innere Medizin

  • Mueller K, Sunami Y, Stuezle M, Güldiken N, Kucukoglu O, Mueller S, Kulaksiz H, Schwarz P, Strnad P. CHOP-mediated hepcidin suppression modulates hepatic iron load. J Pathol. 2013; 231; 532-542
  • Trieß C, von Figura G, Stuhrmann M, Butzeck B, Krayenbuehl PA, Strnad P, Kulaksiz H. Diagnosis of hereditary hemochromatosis in the era of genetic testing. Dig. Dis. Sci. 2012; 57; 2988-2994
  • Jesse S, Lehnert S, Jahn O, Parnetti L, Soininen H, Herukka SK, Steinacker P, Tawfik S, Tumani H, von Armin CA, Neumann M, Kretzschmar HA, Kulaksiz H, Lenter M, Wiltfang J, Ferger B, Hengerer B, Otto M. Differential sialylation of serpin A1 in the early diagnosis of Parkinson`s disease dementia. PLoS One 2012; 7; e48783
  • Theurl I, Schroll A, Nairz M, Seifert M, Theurl M, Sonnweber T, Kulaksiz H, Weiss G. Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo. Haematologica 2011; 96; 1761-1769
  • Esposito I, Kubisova A, Stiehl A, Kulaksiz H. Schirmacher P. Secondary sclerosing cholangitis after intensive care unit treatment: clues to the histopathological differential diagnosis. Virchows Arch 2008; 453; 339-45
  • Toblli JE, Cao G, Rivas C, Kulaksiz H. Heart and iron deficiency anaemia in rats with renal insufficiency: the role of hepcidin. Nephrology (Carlton) 2008; 13;636-645
  • Hampe T, Kulaksiz H. Ileus due colon endometriosis and the role of MRI scan. Int J Colorectal Dis. 2008; 23; 127-8
  • Treede I, Braun A, Sparla R, Kuhnel M, Giese T, Turner JR, Anes E, Kulaksiz H, Fullekrug J, Stremmel W, Griffiths G, Ehehalt R. Anti-inflammatory effects of phosphatidylcholine. J Biol Chem 2007; 282; 27155-27164
  • Merle U, Theilig F, Fein E, Gehrke SG, Kallinowski B, Riedel HD, Bachmann S, Stremmel W, Kulaksiz H. Co-localization of the iron-regulatory proteins hemojuvelin and transferrin-receptor 2 to the basolateral membrane domain of hepatocytes. Histochem Cell Biol 2007; 127; 221-226
  • Harrison-Findik D, Schafer D, Klein E, Timchenko N, Kulaksiz H, Clemens D, Fein E, Pantopoulos K, Andriopoulos B, Gollan J. Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J Biol Chem 2006; 281; 22974-22982
  • Pietrangelo A, Caleffi A, Henrion J, Francesca F, Corradini E, Kulaksiz H, Stremmel W, Andreone P, Garuti C. Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genes. Gastroenterology 2005; 128; 470-479
  • Gehrke SG, Pietrangelo A, Kascak M, Braner A, Eisold M, Kulaksiz H, Herrmann T, Hebling U, Bents K, Gugler R, Stremmel W. HJV gene mutations in European patients with juvenile hemochromatosis. Clin Genet 2005;  67; 425-428
  • Gehrke SG, Herrmann T, Kulaksiz H, Merle U, Bents K, Kaiser I, Riedel HD, Stremmel W. Iron stores modulate hepcidin expression by an HFE-independent pathway. Digestion 2005; 72; 25-32
  • Gehrke SG, Kulaksiz H, Herrmann T, Riedel HD, Bents K, Veltkamp C, Stremmel W. Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron. Blood 2003; 102; 371-376
  • Kulaksiz H, Cetin Y. The electrolyte/fluid secretion stimulatory peptides guanylin and uroguanylin and their common functional coupling proteins in the rat pancreas: a correlative study of expression and cell-specific localization. Pancreas 2002; 25: 170-175
  • Kulaksiz H, Rausch U, Vaccaro R, Renda TG, Cetin Y. Guanylin and uroguanylin in the parotid and submandibular glands: potential intrinsic regulators of electrolyte secretion in salivary glands. Histochem Cell Biol 2001; 115: 527-533
  • Kulaksiz H, Bektas H, Cetin Y. Expression, cell- and membrane-specific localization of NHE-3 in the human and guinea pig upper gastrointestinal tract. Cell Tissue Res 2001; 303: 337-343
  • D’Este, L., Kulaksiz, H., Rausch, U., Vaccaro R., Wenger, T., Tokunaga, Y., Renda T.G., Cetin, Y. Expression of guanylin in „pars tuberalis-specific cell“ and gonadotrophs of rat adenohypophysis. Proc Natl Acad Sci USA 2000; 97: 1131-1136
  • Hill, O., Kuhn, M., Zucht, H.-D., Cetin, Y., Kulaksiz, H., Adermann, K., Klock, G., Rechkemmer, G., Forssmann, W.G., Mägert, H.-J. Analysis of the human guanylin gene and the processing and cellular localization of the peptide. Proc Natl Acad Sci USA 1995; 92: 2046 - 2050
  • Cetin, Y., Kulaksiz, H., Redecker, P., Bargsten, G., Adermann, K., Grube, D., Forssmann, W.G., Bronchiolar nonciliated secretory (Clara) cells: Source of guanylin in the mammalian lung. Proc Natl Acad Sci USA 1995; 92: 5925 - 5929
  • Kuhn, M., Kulaksiz, H., Cetin, Y., Frank, M., Nold, R., Arnold, R., Böker, K., Bischoff, S. C., Manns, M. P., Forssmann, W.G. Circulating and tissue guanylin immunoreactivity in intestinal secretory diarrhoea. Europ J Clin Invest 1995; 25: 899 - 905
  • Cetin, Y., Kuhn, M., Kulaksiz, H., Adermann, K., Bargsten, G., Grube, D., Forssmann, W.G. Enterochromaffin cells of the digestive system: cellular source of guanylin, a guanylate cyclase-activating peptide. Proc Natl Acad Sci USA 1994; 91: 2935 - 2939
  • Mueller K, Sunami Y, Stuezle M, Güldiken N, Kucukoglu O, Mueller S, Kulaksiz H, Schwarz P, Strnad P. CHOP-mediated hepcidin suppression modulates hepatic iron load. J Pathol. 2013; 231; 532-542
  • Trieß C, von Figura G, Stuhrmann M, Butzeck B, Krayenbuehl PA, Strnad P, Kulaksiz H. Diagnosis of hereditary hemochromatosis in the era of genetic testing. Dig. Dis. Sci. 2012; 57; 2988-2994
  • Jesse S, Lehnert S, Jahn O, Parnetti L, Soininen H, Herukka SK, Steinacker P, Tawfik S, Tumani H, von Armin CA, Neumann M, Kretzschmar HA, Kulaksiz H, Lenter M, Wiltfang J, Ferger B, Hengerer B, Otto M. Differential sialylation of serpin A1 in the early diagnosis of Parkinson`s disease dementia. PLoS One 2012; 7; e48783
  • Theurl I, Schroll A, Nairz M, Seifert M, Theurl M, Sonnweber T, Kulaksiz H, Weiss G. Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo. Haematologica 2011; 96; 1761-1769
  • Esposito I, Kubisova A, Stiehl A, Kulaksiz H. Schirmacher P. Secondary sclerosing cholangitis after intensive care unit treatment: clues to the histopathological differential diagnosis. Virchows Arch 2008; 453; 339-45
  • Toblli JE, Cao G, Rivas C, Kulaksiz H. Heart and iron deficiency anaemia in rats with renal insufficiency: the role of hepcidin. Nephrology (Carlton) 2008; 13;636-645
  • Hampe T, Kulaksiz H. Ileus due colon endometriosis and the role of MRI scan. Int J Colorectal Dis. 2008; 23; 127-8
  • Treede I, Braun A, Sparla R, Kuhnel M, Giese T, Turner JR, Anes E, Kulaksiz H, Fullekrug J, Stremmel W, Griffiths G, Ehehalt R. Anti-inflammatory effects of phosphatidylcholine. J Biol Chem 2007; 282; 27155-27164
  • Merle U, Theilig F, Fein E, Gehrke SG, Kallinowski B, Riedel HD, Bachmann S, Stremmel W, Kulaksiz H. Co-localization of the iron-regulatory proteins hemojuvelin and transferrin-receptor 2 to the basolateral membrane domain of hepatocytes. Histochem Cell Biol 2007; 127; 221-226
  • Harrison-Findik D, Schafer D, Klein E, Timchenko N, Kulaksiz H, Clemens D, Fein E, Pantopoulos K, Andriopoulos B, Gollan J. Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J Biol Chem 2006; 281; 22974-22982
  • Pietrangelo A, Caleffi A, Henrion J, Francesca F, Corradini E, Kulaksiz H, Stremmel W, Andreone P, Garuti C. Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genes. Gastroenterology 2005; 128; 470-479
  • Gehrke SG, Pietrangelo A, Kascak M, Braner A, Eisold M, Kulaksiz H, Herrmann T, Hebling U, Bents K, Gugler R, Stremmel W. HJV gene mutations in European patients with juvenile hemochromatosis. Clin Genet 2005;  67; 425-428
  • Gehrke SG, Herrmann T, Kulaksiz H, Merle U, Bents K, Kaiser I, Riedel HD, Stremmel W. Iron stores modulate hepcidin expression by an HFE-independent pathway. Digestion 2005; 72; 25-32
  • Gehrke SG, Kulaksiz H, Herrmann T, Riedel HD, Bents K, Veltkamp C, Stremmel W. Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron. Blood 2003; 102; 371-376
  • Kulaksiz H, Cetin Y. The electrolyte/fluid secretion stimulatory peptides guanylin and uroguanylin and their common functional coupling proteins in the rat pancreas: a correlative study of expression and cell-specific localization. Pancreas 2002; 25: 170-175
  • Kulaksiz H, Rausch U, Vaccaro R, Renda TG, Cetin Y. Guanylin and uroguanylin in the parotid and submandibular glands: potential intrinsic regulators of electrolyte secretion in salivary glands. Histochem Cell Biol 2001; 115: 527-533
  • Kulaksiz H, Bektas H, Cetin Y. Expression, cell- and membrane-specific localization of NHE-3 in the human and guinea pig upper gastrointestinal tract. Cell Tissue Res 2001; 303: 337-343
  • D’Este, L., Kulaksiz, H., Rausch, U., Vaccaro R., Wenger, T., Tokunaga, Y., Renda T.G., Cetin, Y. Expression of guanylin in „pars tuberalis-specific cell“ and gonadotrophs of rat adenohypophysis. Proc Natl Acad Sci USA 2000; 97: 1131-1136
  • Hill, O., Kuhn, M., Zucht, H.-D., Cetin, Y., Kulaksiz, H., Adermann, K., Klock, G., Rechkemmer, G., Forssmann, W.G., Mägert, H.-J. Analysis of the human guanylin gene and the processing and cellular localization of the peptide. Proc Natl Acad Sci USA 1995; 92: 2046 - 2050
  • Cetin, Y., Kulaksiz, H., Redecker, P., Bargsten, G., Adermann, K., Grube, D., Forssmann, W.G., Bronchiolar nonciliated secretory (Clara) cells: Source of guanylin in the mammalian lung. Proc Natl Acad Sci USA 1995; 92: 5925 - 5929
  • Kuhn, M., Kulaksiz, H., Cetin, Y., Frank, M., Nold, R., Arnold, R., Böker, K., Bischoff, S. C., Manns, M. P., Forssmann, W.G. Circulating and tissue guanylin immunoreactivity in intestinal secretory diarrhoea. Europ J Clin Invest 1995; 25: 899 - 905
  • Cetin, Y., Kuhn, M., Kulaksiz, H., Adermann, K., Bargsten, G., Grube, D., Forssmann, W.G. Enterochromaffin cells of the digestive system: cellular source of guanylin, a guanylate cyclase-activating peptide. Proc Natl Acad Sci USA 1994; 91: 2935 - 2939

Übersichtsarbeiten

  • Figura G, Kulaksiz H. Diagnosis and treatment in hereditary hemochromatosis. Dtsch Med Wochenschr 2009; 134;2565-2572
  • Strnad P, Zatloukal K, Stumptner C, Kulaksiz H, Denk H. Mallory-Denk-bodies: Lessons from keratin-containing hepatic inclusion bodies. Biochim Biophys Acta 2008; 1782;764-774

Andere Publikationen

  • Forssmann WG, Cetin Y, Hill O, Mägert HJ, Kuhn M, Kulaksiz H, Rechkemmer G. Guanylin is a new gastrointestinal hormone regulating water-electrolyte transport in the gut. In: Symposium on Gastrointestinal Tract and Endocrine System. Falk Symposium 1994;77 (Singer, M. V., Ziegler, R.), MTP Press, Lancester, U. K
  • Kuhn M, Cetin Y, Kulaksiz H, Hill O, Mägert HJ, Forssmann WG. Guanylin: a new gastrointestinal hormone that stimulates guanylate cyclase C. In: Hepato-Gastroenterology. Current medical and surgical trends (Lygidakis, N. J., Moreno Gonzales, E.). Georg Thieme Verlag Stuttgart - New York 1994; 41: 91 - 92.